PROGRESS SAVED ON THIS DEVICE
My space
UNIT 05 / REVIEW

Sources of genetic variation

Crossing over, independent assortment, and random fertilization reshuffle existing alleles. Mutation creates new alleles.

See all Unit 5 topics
01 / Sources of genetic variation

Sources of genetic variation

Crossing over exchanges corresponding DNA segments between nonsister chromatids of paired homologs during prophase I. Different homolog pairs orient independently at metaphase I, producing different combinations of maternally and paternally inherited chromosomes. Even without crossing over, n chromosome pairs can generate 2^n chromosome combinations through independent assortment. Random union of gametes adds further combinations. Recombination changes combinations; it does not intentionally generate alleles that an organism needs.

MAKE IT CONCRETE

An organism with n = 4 has 16 possible whole-chromosome combinations in gametes from independent assortment alone; crossing over increases the possible sequence combinations.

DON’T FALL FOR THIS

Independent assortment describes how different homolog pairs orient, not sister chromatids randomly forgetting where to go.

Keep going

Original review notes informed by standard biology principles. Check the official AP Biology framework ↗ and OpenStax Biology 2e ↗ for further reading.